Avneet Saini, Ph.D.
Peptide Design and Characterization Group
I'm an Assistant Professor in the Department of Biophysics, Panjab University, Chandigarh (India).
We work on designing peptides for various applications ranging from therapeutics to Diagnostics. Our work also includes the development of peptide-based biomaterial coatings for biomedical applications and material science.
The underlying theme of our research is Design and Structural Characterization of novel peptides/ peptidomimetics to solve the challenges posed by existing molecules. In this endeavor we make use of a range of Computational Biology, Molecular Biophysics, and Biophysical Chemistry Techniques.
We also work on the development of peptide-based nano-bioconjugates. The modification of abiotic nano-surfaces with active biomolecules such as peptides extends the potential applications of nanomaterials in various fields. The bound bioconjugate could improve the biocompatibility and bio-recognition ability of various nano-composites, and hence, greatly enhance their biosensing performances on selectivity and sensitivity.
Many of our projects are directed toward biological problems of therapeutic relevance, sensing as well as Biomaterials.
We have an extensive network of interdisciplinary collaborations, within Panjab University, and other institutions nationally and internationally.
Saini S, Khurana S, Saini D, Rajput S, Thakur CJ, Singh J, Jaswal A, Kapoor Y, Kumar V, Saini A. In silico analysis of genomic landscape of SARS-CoV-2 and its variant of concerns (Delta and Omicron) reveals changes in the coding potential of miRNAs and their target genes. Gene. 2023 Feb 15;853:147097. DOI: 10.1016/j.gene.2022.147097
Sheetal Sharma, Hemant Goyal, Shubhi Joshi, Bimla Nehru, Avneet Saini, Molecular interactions of resveratrol with Aβ 42 peptide and fibril during in-vitro Aβ 42 aggregation, Advances in Redox Research, Volume 7, 2023, 100060, ISSN 2667-1379, https://doi.org/10.1016/j.arres.2023.100060
Sharma, P., Sharma, S., Joshi, S., Barmab P., Bhatt A., Maan M., Singla N., Rishi P., Ali Md. E., Preet S., Saini A., Design, characterization and structure–function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment. Sci Rep 12, 12058 (2022). https://doi.org/10.1038/s41598-022-16303-2.